Discordance between IGRAs and TST has been related to BCG vaccination, [ 27- 29] and to superior specificity of the IGRAs, at least in certain settings[ 15].
Oligonucleotide microarrays have become a widely used alternative to cDNA microarray because of their superior specificity, reproducibility, and ease of design (20).
As evidence of the superior specificity and similar sensitivity of anti-CCP as compared to RF as a predictor of an adverse outcome in inflammatory arthritis has increased [ 3, 5- 7], the question of whether one should stop testing for RF has been raised [ 29].
These techniques are often complementary to anatomical imaging, as a result of their superior specificity and the ability to perform total-body imaging, which can identify multifocal disease or distant metastases that may otherwise evade detection.
While higher thresholds of ALT provided superior specificity, rates of false negatives increased ~2-fold (18 30 %) and the negative predictive value decreased from 82 71 % (Table 2).
None of the peaks showed superior specificity to that of CA125 when analyzed alone.
Surprising, however, was the difference in positivity between the CLIA (4.1%) and IIF (21.2%) tests in the control group, made up of healthy individuals, thus emphasising the clearly superior specificity of the CLIA assay.
The superior specificity of MS allows the simplification of sample preparation, and the application of fast gradient methods, where a baseline separation of all components is not required.
The results indicate the existence of strong hemodynamic abnormalities in non-dilated type-I BAV AAs, their colocalization with sites vulnerable to dilation and the superior specificity of WSS metrics over global hemodynamic metrics to the valve anatomy.
The superior specificity of anti-citrullinated protein antibody tests has somewhat diminished interest in rheumatoid factor at time of diagnosis of rheumatoid arthritis, but not necessarily when it comes to prediction of long term risk.
