For lack of sufficient long-term studies there are still concerns about the long-term safety of topical corticosteroids.
At present, there is a lack of sufficient long-term data about the safety of infliximab in patients with plaque psoriasis.
However, the potential for evaluating and testing these approaches is often limited due to the lack of sufficient long-term data on ecosystems and environmental change [ 13].
Note that we assume that the hardware clock is a linear function of real time within a sufficient long period of time.
Instead, a sufficient long opening of plasma membrane channels could produce the same sustained Ca2+ increase.
As was suggested by Haldberg et al. [77], 'in biologic time series that are dense and sufficient long the characteristics of rhythms and trends can be quantified as elements of structures called chronoms'.
But without sufficient long-term financing options, few can take the risk of starting construction.
Consequently, researchers have tried to establish whether reducing the number of cigarettes smoked could bring about sufficient long-term health benefits to be recommended as a worthwhile alternative to quitting.
However, as demonstrated by Weinstein's review [ 33], the challenges of implementing a randomised controlled study design of sufficient power, with long term follow-up is limited by both subject non-adherence to randomisation and the ethical considerations around use of a true control group.
There is also a lack of sufficient information on the long term results of growth hormone treatment in children of short stature.
50 The tentative "sociogenetic" link indicated by our results could mean that psychosocial trauma of sufficient gravity and with long term negative emotional and disruptive immunological consequences could increase the risk of an existing genetic vulnerability leading to the development of the corresponding disease.
