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This model was used in the course of designing and setting of such a screen in LPMC.
The only requirement for performance of such a screen is a good antibody that recognizes structures within the tissue in question.
The output of such a screen typically yields unoptimized chemical start points which are then advanced through various biological assays to derive a valuable clinical candidate.
A recent variant of such a screen used early pressure to identify several mutants that affected T-cell development [ 20, 33].
One example of such a screen was based on a simple experiment designed to identify a small molecule capable of replacing the transcription factor Sox2 [ 18].
To examine the feasibility of such a screen, we performed sensitized phenotyping in five therapeutic areas (metabolic syndrome, immune dysfunction, atherosclerosis, cancer and behaviour) of a 0.8 Mb reciprocal chromosomal duplication and deficiency on chromosome 11 containing 27 genes.
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"Anything short of such a screening, referral and assessment may risk putting already vulnerable individuals at grave risk of danger".
The objective is to specify one among several possible variants of such a screening test.
In this context, we evaluated the interest of such a screening in 2004 in France.
Recent research showed that the exclusion of such a screening question led to high telescoping (Reep 2013a, 2014).
However, the overall benefit of such a screening strategy is limited since more than 38% of the 659 patients without abnormality had a decreased PCAT-NR.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com