The clinical impact of such a diagnostic refinement based on molecular marker is relevant as astrocytoma presents more aggressive progression than oligodendroglioma, and accordingly a diagnosis of an astrocytic tumor requires more aggressive therapeutic strategies.
The investment in such a refinement of the risk assessment, e.g., in the form of mathematical models or more complex experimental studies (aquatic mesocosms, and field studies) is usually worthwhile for the applicant company.
Though our method can provide a generalized overview of the resources used (and their order of use), such a refinement could enable more fine-grained workflow extraction an important step towards method validation and reproduction, as well as having implications for the spreading of knowledge and the monitoring of trends within methods.
Even if we don't get closer to a clear history of cellular lineages, such a refinement might allow us to focus on network features that correspond to LGT highways that are at least partially adaptive.
The general problem we address is the following: Given a non-binary gene tree G and a species tree S, find a refinement of G containing the minimum number of NADs with respect to S. Such a refinement of G is called a minimum refinement of G w.r.t. S. Hence, we aim at refining each non-binary node of G.
Myers' string graph is a refinement of such a graph.
In this paper, such a refinement of (1) is obtained.
The evaluation of right ventricular function during the acute NTG-induced pulmonary vasodilation was of critical importance in obtaining such a refinement in the prognostic stratification.
The in vivo, local spatial configuration of DNA into structural loops, as determined by the present protocol, constitutes the starting point for any further refinement or modification of such a configuration by chromatin proteins and epigenetic mechanisms affecting chromatin structure.
The mechanism of such grain refinement in cast Zn was investigated through varying the addition level of this peritectic-forming solute.
One piece in "Dining Alone," Annie-B Parson's "Short Ride Out," provides a glimpse of such refinement.
