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The kindred was initially identified through the proband who – despite being homozygous for β°-thalassemia, with a complete absence of adult hemoglobin (HbA; α2β2) – had an extremely mild clinical phenotype which was the result of substantially raised HbF expression.
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It would involve some combination of substantially raising the retirement age, sharply reducing cost-of-living adjustments and heavily taxing those private accounts when they are cashed in.
The long-term Medicaid cuts in the Senate bill are even deeper than in the House bill, and Cruz's amendment would have the effect of substantially raising prices on people with pre-existing conditions in the name of lowering prices for the healthy.
She said it would be impossible to "substantially raise the standard of care" without a significant increase in Government spending.
The controlled release of water was intended to take pressure off the dam, but was not expected to substantially raise the level of the river.
But most candidates, including Ms. Quinn, a Democrat, demurred when asked if they would pledge to substantially raise the share of the city budget devoted to mass transit.
SHANGHAI — For the second time in a week, Foxconn Technology, the world's largest contract electronics manufacturer, said that it planned to substantially raise the salaries of its huge Chinese workforce.
What's more, Twenty20 stands to substantially raise the value of the team's younger and newly ascendant players; cricketers are already some of the best-paid mascots in this country, for things as varied as motor oil and cellphone service.
Moreover, recent overviews of prospective observational studies indicate that although the risk of coronary heart disease is linearly and modestly increased above a fasting glucose value of 5 mmol/L, the risk of stroke is substantially raised only at fasting glucose values well above 7 mmol/L (fig 4 in supplementary analysis on bmj.com).
Levels of PAR were substantially raised in RNaseH2null MEFs, as shown by immunoblotting, confirming the presence of cellular DNA-strand breaks.
It is evident that, if the number of evaluators is substantially raised, these discrepancies tend to diminish, and would also enable the analysis using mean values.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com