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The synthesis of substantially larger genomes is more difficult and is unlikely to constitute a real bioterror threat in the immediate future.
However, the relatively small sample sizes used here do not rule out the possibility of consistent yet subtle changes in gene expression being detected in case-control analyses of substantially larger cohorts.
For hexanucleotides there are 46 = 4096 possible combinations resulting in large vectors containing far more detail, but also the requirement of substantially larger amounts of DNA.
Thus, the significant difference in EMG latencies among areas is probably not a function of substantially larger numbers of corticospinal neurons (CSNs) that were activated in different areas.
The requirement of a separate, prior consent stage may significantly reduce overall survey response rates and necessitate the use of substantially larger initial samples for population surveys.
In summary, it is unlikely that the conclusion of substantially larger benefits from cycling than risks is strongly affected by the assumptions made in the scenario, including the use of data from the Netherlands.
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The sum kernel limits the applicability of PBEs to substantially larger particle populations than that seen for the constant kernel.
The credibility of study would be increased by analysis of the substantially larger number of cancer networks, or maybe other (non-cancer) networks for which the similar reasoning is possible, to show that Betti number #11,1 is a good measure of network robustness.
While the median performs slightly better (i.e. by up to 1.03 times better, or 78.9 over 76.3) than the mean when used as a threshold for the proportion of disease genes among interactors, this improvement is at the expense of generating substantially larger lists of candidate genes.
The review calls for a comprehensive assessment of a substantially larger number of chemicals in the pool area than the limited number of DBPs studied to date.
For a programme of screening at next registration, delivery costs are greater in Italy as a result of the substantially larger proportion of the population captured (63% screened, with 32% receiving a brief intervention versus 39%and13%3% respectively in England).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com