Sentence examples for of substantial problems from inspiring English sources

"It's a sign of substantial problems between union leaders and members.

Nonetheless, experts said the regulators' actions were unusual measures taken because of substantial problems with the way the Bank of New York supervised accounts handling funds from overseas, particularly from Russia.

Nonetheless, analysts said that the enforcement action is an unusual measure taken because of substantial problems with the way the Bank of New York supervised accounts handling funds from overseas -- particularly from Russia.

The Cochrane Collaboration, an academic group, has warned of "substantial problems" with trials of the drug which was stockpiled by governments around the world at a cost of billions of pounds during the 2009 flu pandemic.

However, this may require additional data collection and the overcoming of substantial problems of data linkage, which can be justified only if additional variables improve risk adjustment.

However, while cloning is widely used in basic research, as well as in some biomedical and agricultural applications, a number of substantial problems exist with the current technologies, including relatively low success rates and severe defects of the fetus and/or placenta resulting in abortion, neonatal death and postnatal disease [ 2- 4].

Coupling existing large-scale bottom-up and top-down models [46]; Böhringer and Rutherford call this a "soft-link" because of the substantial problems in consistency and convergence of iterative solution algorithms.

Combined bottom-up and top-down approaches can be categorized following Böhringer and Rutherford [32]: Coupling existing large-scale bottom-up and top-down models [46]; Böhringer and Rutherford call this a "soft-link" because of the substantial problems in consistency and convergence of iterative solution algorithms.

Unfortunately, the vast majority of studies conducted in support of split-foveal processing fail to adhere to either of these requirements (for a description of the substantial problems that exist in previous research in this area, see [4], [5]).

This position leaves us with a number of quite substantial problems.

Stephen Walsh, the author of a magisterial, evenhanded biography of Stravinsky, describes in his introduction substantial problems of "factual or even textual accuracy" in the diaries, letters and other books published by Mr. Craft after Stravinsky's death.