Sentence examples for of substantial efficacy from inspiring English sources

This approach has recently received a major impetus from the preliminary report of substantial efficacy in a controlled trial in rheumatoid arthritis [ 24].

They report evidence of substantial efficacy with an overall response rate of 80%, including 45% with complete response, and a time to progression of 12 months.

The substantial efficacy of imatinib mesylate in the treatment of advanced and recurrent gastrointestinal tumors (GISTs) has been confirmed by clinical trials in the past decade.

Improving the prognosis for patients with acute TBI is critical [ 23] as TBI remains a devastating disease associated with considerable mortality and morbidity and a huge burden to society, and there are no interventions that show substantial efficacy despite of hundreds of trials [ 24, 25].

Randomised controlled trials demonstrated substantial efficacy of anti-TNFα therapy in ankylosing spondylitis (AS) [ 1- 3] and psoriatic arthritis (PsA) [ 4- 6], with high drug continuation rates [ 7, 8].

Second, the meta-analysis on MTX → FU included several trials designed without the demonstrated optimal interval between the antifol and the fluoropyrimidine (4 24 h) leaving hope for more substantial efficacy of this sequence with appropriate scheduling, as we chose for our study.

Studies in sepsis of goal directed therapy show substantial efficacy when started early [ 15] but not once organ failure is established [ 16].

As an alternative, several novel endocrine therapies have shown substantial efficacy in the setting of CRPC.

While the finding of substantial antiproliferative efficacy is promising, data from the CLARINET study are expected to corroborate findings.

Low-level laser (light) therapy (LLLT) is an alternative approach with no known side effects and with reports of substantial therapeutic efficacy in osteoarthritis.

The combination of both drugs is well tolerated and has shown substantial efficacy in MBC.