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We also found that the total ventilated lung area remained unaffected during mechanical ventilation of substantial duration.
While this might be a significant factor in brain examinations that include dynamic PET measurements of substantial duration, the increase in scan time for the head and neck region is much less pronounced.
Only longitudinal studies of substantial duration that incur natural progression of disease (or biomarkers thereof) would be of value to highlight a retarded progression of age-related diseases induced by therapeutics (e.g., similar to those using statin drugs [ 20, 21], fish oil [ 22], or vitamin supplements [ 23] for prevention of cardiovascular disease).
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For a mission duration of substantial length, the use of thermal mass to maintain an operable temperature range is likely impractical, and active refrigeration may be required to keep components at a temperature below ambient.
Substantial duration of contact is thought to be required for the cell-cell interaction to be effective, e.g. for the TC to deliver the cytotoxins that kill the APC that is infected by viruses.
Thus, the populations had substantial duration of exposure to various factors in their home regions and little exposure outside of these regions.
Adaptation with a slow time constant could explain the fairly substantial duration of the local search but not its sharp transition to a global search.
Moreover, treatment must likely occur over a substantial duration of time, since macrovascular outcome events are known to be late complications of a progressive multifaceted pathogenic process that spans decades [ 7, 8].
"We have to come up with new, innovative strategies, of substantial scale and duration, to address demand.
Although it remains possible that anti-B-cell therapy is not sufficient to suppress lupus activity, a number of other confounding variables of SLE trial design may have substantially contributed (too short trial duration, allowance of substantial glucocorticoid usage, heterogeneity of the patient population, etc).
For example, there are several important aspects of privacy, including the incorporation of privacy protections within a business organization and the maintenance of substantial data management procedures for the duration of the cycle of products/services [30].
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CEO of Professional Science Editing for Scientists @ prosciediting.com