Sentence examples for of substantial difficulty from inspiring English sources

At 2100 mg BID grade 3 anorexia and a combination of grade 3 anorexia and fatigue yielded protocol-defined DLT in two patients, but because of substantial difficulty with capsule intake experienced by all other patients at this dose, capsule load at 2100 mg BID was considered dose limiting as well, albeit not defined by protocol.

Because of deep beliefs motivating people to commit their lives in spite of substantial difficulties, we speak of a technological ideology.

We use some approaches to prove the global existence-boundedness of classical solutions and overcome the substantial difficulty of the existence of a nonlinear prey-taxis term.

But, he said, 10percentt of the patients had substantial difficulty acknowledging the nature and severity of their disease, a problem that could call their decision-making capacity into question.

Note that the gradient term in the right-hand side of (1.1) will bring substantial difficulty to the research.

The additional germ line cells occupy locations near somatic cells of interest throughout the trunk of the worm, which poses a substantial difficulty for annotation approaches that rely on location-based features alone.

It appears then that patients in stage 1 of the disease as a result of mild symptoms do not have substantial difficulty in their daily lives.

The time points of all participant-related actions to be taken during the study period are presented in table 1. Retaining participants in a clinical trial of long-term duration represents a substantial difficulty for research teams.

These results show the substantial difficulty associated with the aim of searching for all published cases.

All (four) patients in the 2100-mg cohadt had substantial difficulty with the capsule load (seven capsules of 300 mg BID).

Initial experience revealed substantial difficulties of the students to handle the amount and complexity of the results of the CGA.