Sentence examples for of substantial difficulties from inspiring English sources
Because of deep beliefs motivating people to commit their lives in spite of substantial difficulties, we speak of a technological ideology.
At 2100 mg BID grade 3 anorexia and a combination of grade 3 anorexia and fatigue yielded protocol-defined DLT in two patients, but because of substantial difficulty with capsule intake experienced by all other patients at this dose, capsule load at 2100 mg BID was considered dose limiting as well, albeit not defined by protocol.
Initial experience revealed substantial difficulties of the students to handle the amount and complexity of the results of the CGA.
However, considering the closed nature of the position, White faces substantial difficulties in the realisation of this nominal advantage".
But retooling the fast-growing industry of factor production posed substantial difficulties, for several reasons.
The authors concluded that especially the dose assessment of CT examinations pose substantial difficulties for non-radiologists.
By ' long- standing' I mean anything that has troubled you over a period of at least 12 months or that is likely to trouble you over a period of at least 12 months.' If participants respond in the affirmative they are then asked ' Does this/ Do these health problem (s) or disability (ies) mean that you have substantial difficulties with any of these areas of your life?
In particular, the nonlocal structure of the fractional operators induce substantial difficulties in their analysis and significant dissimilarities in comparison with their integer-order counterparts.
Any change or addition to the physics model would require a reformulation of the adjoint problem and substantial difficulties in its software implementation.
In addition, it is then necessary to separate the dispersed phase which can be a major drawback of the operation sometimes posing substantial difficulties in easily emulsified liquid liquid systems or in easily foamed gas liquid systems.
While the problem of added predictive value has long been addressed in the literature for low-dimensional models, literature on added predictive value of signatures derived from high-dimensional data is scarce [ 11], although the high dimension of the predictor space adds substantial difficulties that have to be addressed by adapting classical methods.
