A "top-down," integrative model predicting limited phenotypes from genotyping for Mycoplasma genitalium is available [ 24]; top-down predictions of virulence, however, add the substantial complexity of host interactions.
The issue is particularly relevant in light of the multi-dimensional nature and the substantial complexity of UWM systems, as well as for the high criticality level assumed by these systems in recent years.
We have also described the substantial complexity of the genetic analysis of the IL-28B locus, and we have presented a new approach to identifying samples with particular IL-28B genotypes for functional studies.
The analysis of metagenomic sequences using bioinformatics pipelines is complicated by the substantial complexity of these data.
These peripheral lymphoid tissues and organs develop prior to the individual's exposure to external antigens, and despite their similar functions, their varied appearances indicate a substantial complexity of tissue ontogeny.
However, at the same time, availability of such radicals adds substantial complexity to the elementary cell, and this fact has influence upon the structure of the spectrum of electronic states, particularly, upon the energy structure of the conductivity band.
In recent years metagenomics (the study of genetic content of entire communities recovered directly from environmental samples) has provided new insights into the substantial complexity and diversity of RNA viruses of invertebrates1.
Genetic and genomic studies highlight the substantial complexity and heterogeneity of human cancers and emphasize the general lack of therapeutics that can match this complexity.
This long latency adds substantial complexity to the evaluation of causality and assessment of infection control strategies at both a population and individual level.
