Instrumental aspects of care refer to substantial activities, such as giving bed bath and providing medical information, which promote physical comfort and cognitive coping [ 5].
A phase II trial of bevacizumab plus erlotinib revealed substantial activity of this combination in patients treated previously or patients who had not received treatment because of the presence of poor-prognostic features (Hainsworth et al, 2007).
Methanol extract (22.63 mm against P. aeruginosa) and n-butanolic fraction (22.83 against B. subtilis) of stem showed substantial activity.
As expected, uridine completely prevented the activation of caspases-3/7 in the cells with normal ATF4 levels, but a substantial activity of caspase-3/7 (73–76% of the positive control) was observed in the cells with ATF4 knockdown.
Moreover, substantial activity of one isoenzyme may compensate for the reduced activity of another one [ 34].
Omlin et al (2013) report the anti-tumour activity of diethylstilbestrol (DS) and abiraterone (AA) in castration-resistant prostate cancer and suggest substantial activity of AA in DS pretreated patients.
Although the optimum temperature of XynGR67 was 40°C, substantial activity remained at low temperatures (22.5% at 10°C and 8.2% at 0°C).
There is another question particularly salient for the seventeenth century philosopher: What kinds of causes are present in substantial activity?
Unlike the other members of the family, HPR displays substantial activity on double stranded (ds) RNA even under conditions in which dsRNA maintains stable secondary structure [2].
