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Phylogenomic trees of domain structures at FF level of structural abstraction were reconstructed from the data matrix of genomic abundances (multiple occurrences of FFs) using maximum parsimony (MP) with 1,000 replicates of random taxon addition, tree bisection reconnection branch swapping, and maxtrees unrestricted.
Over 107 proteins have been assigned to folds, fold superfamilies, and FFs in over 1,400 proteomes and trees of domain structures have been reconstructed at all levels of structural abstraction [ 17, 19- 21].
For the most part, structure-function relationships are unambiguous at the FF level of structural abstraction.
Three masters of structural abstraction at the height of their powers.
Here we study the evolution of protein domains at the FF level to determine if lower levels of structural abstraction still preserve these ancient signatures.
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The clear reduction of the number of universal domain structures with lower levels of structural abstractions is expected and showcases the decreased evolutionary conservation of FFs relative to fold superfamilies and folds.
First, we provide a new formalization for structural abstraction that generalizes and extends previous ones.
In this paper, we consider one of the types of abstraction commonly used in diagnosis, i.e., structural abstraction, investigating it both from a theoretical and practical point of view.
Our main result is the elaboration of structural properties that (a) allow for abstraction based controller design and that (b) are preserved under closed-loop composition.
MONTCLAIR Montclair Art Museum PatternsSystemsemStructuresres: Abstraction in American Art," exhibition exploring the variety of approaches to abstraction.
"Patterns, Systems, Structures: Abstraction in American Art," an exhibition that explores the variety of approaches to abstraction in American art.
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