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A number of strong candidate TSGs were recently reported for 1p, including the CHD5 gene [13] and the microRNA-34a [14].
We have established a list of strong candidate genes encoded by the regions linked to various nonsyndromic hereditary hearing loss phenotypes by using a novel bioinformatic approach.
Incorporation of this information into tumor mutation profile analyses will enhance predictive ability, promoting effective discovery of strong candidate cancer genes for subsequent study.
This analysis highlighted a list of strong candidate genes from the TGF-β, MAPK and Hedgehog signalling pathways, which are all integral to fetal development and potential targets for alcohol's teratogenic effect.
Briefly, in these studies the P-value should cross a restrictive threshold (usually established at 10−7 or 10−8) to obtain a list of strong candidate genes that can be, finally, replicated in small populations.
These panels included NSHL genes with a DFN locus annotation and syndromic HL genes, as well as a limited number of strong candidate HL genes (i.e., from animal experiments).
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