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The lack of stringent quality criteria led to the development of many QSAR models in the past that lacked sufficient validation and reliability to make them adequate for regulatory use.
We applied a number of stringent quality checks to all genotype calls derived from these arrays to define a subset of high quality SNPs (see Methods).
The annotation must also pass a number of stringent quality assurance tests.
Notably, moderate deviations within the upper tail of the distribution were found in all QQ plots, in spite of stringent quality control and inclusion of up to top five PCs.
The application of stringent quality criteria inevitably caused a reduction of the number of SNPs available to the analysis, with the obvious advantage of providing, on the other hand, a more reliable genotype data set.
In the context of other evidence of poor rapid test performance in the field, our findings support an urgent call for the implementation of stringent quality control and assurance measures where they do not already exist.
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We applied a series of stringent quality-control steps to clean up raw reads before they were used for single-nucleotide polymorphism (SNP) calling.
The key findings of our work suggest the necessity for stringent quality control of POCT as the quality of testing seem to vary between clinics.
Procedures for stringent quality control of the SNP data and for imputation to 729 068 SNPs are described in Bolormaa et al. [ 15].
These packages are subject to stringent quality control in terms of functionality and documentation.
We aimed for stringent quality control.
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