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These fourth-generation agents provide a real degree of therapeutic comfort in terms of stable activity, a reduction in adverse effects and a broad therapeutic spectrum, especially in myocardial ischaemia and potentially in congestive heart failure.
Instantaneous firing frequency histograms were compiled by extracting the inter spike intervals from 6 minute long periods of stable activity.
In the present study, we demonstrate that an oscillatory model network, consisting of more than 2 cells, fully interconnected with fast inhibitory and electrical synapses, generates a large variety of stable activity patterns, the number of which depends on the number of cells as well as on the coupling parameter domain (see Fig. 2).
However, in these networks we were unable to identify parameters that support formation of stable activity bumps.
It is possible that the laboratory environment with limited space for experiencing or exercising movement did not stimulate the formation of stable activity types.
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Our in silico results have predicted that a general repression of the Wg pathway is required for stable activity of Notch at the DV boundary.
This regulation of SMAD1/5 signaling was specific and in contrast to stable activity of the alternative SMAD2 pathway.
To determine which polymerase subunit(s) are required for stable activity of RNA polymerase on thermal stress in 293T cells, we constituted artificial hybrid polymerases and measured the steady-state levels of mRNA, cRNA and vRNA.
Thus, in this sense, the results correspond to previous work showing that various combinations of components give rise to stable activity.
CS, the pace-maker enzyme in the citric acid (Krebs) cycle, is commonly used as quantitative marker for the evaluation of intact mitochondria content, because of its stable activity.
However, even such a simplified network is able to qualitatively represent the emergent property of a stable activity pattern that mimics a working memory property, as evidenced by the similarity of the model outcome with electrophysiology readings in primates performing such a task [ 11].
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