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The randomised placebo controlled trial is the gold standard for the evaluation of specific efficacy, for instance of newly regulated drugs.
5 Although some distinguish between pure and impure (or inert and active) placebos, it is the lack of specific efficacy that is based on the inherent properties of a compound that makes an intervention a placebo.
Despite the absence of specific efficacy objectives in the protocol design, the quarterly safety assessments provided results regarding the effects of velaglucerase alfa treatment on hemoglobin concentration and platelet count.
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17 Therefore, it is important to estimate to what degree the observed outcomes from invasive procedures are due to specific efficacy of the treatments or to other factors.
An adequate evaluation of the specific efficacy of each of its components, however, has not been done.
In the absence of any specific efficacy data, the efficacy of the additional serotypes in PHiD-CV and PCV-13 had to be estimated using the average efficacy of the serotypes in PCV-7, but their true efficacy may lie at either extreme of the efficacy range (87% for 19F to 99.9% for 9V).
Histamine-2 receptor (H2) blockers are often used in very low birth weight infants despite lack of population specific efficacy and safety data.
The existing evidence mosaic can be enhanced by randomised controlled trials that investigate the specific efficacy of different components of acupuncture.
Clinical investigations of integrative care have typically evaluated the specific efficacy of various therapies in isolation.
Most research studies have investigated different CTs in isolation, i.e. assessed specific efficacy of individual components in models of care.
However, specific efficacy of these inhibitors against one or more forms of breast cancer has not been described.
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CEO of Professional Science Editing for Scientists @ prosciediting.com