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Morpholino antisense oligos (MAOs) are used to investigate physiological gene function by inhibiting gene translation or construction of specific alternative splicing variants by blocking cis-splicing.
DM1-associated defects are remarkably similar to those observed in Mbnl1 knockout mice and include myotonia, ocular cataracts, histological abnormalities, and the abnormal use of specific alternative exons [9], [10].
Table 5 compares the achievement of conceptual equivalence of specific alternative terminology as compared to bother.
More in-depth EST sequencing of more plants should clarify the existence and possible roles of specific alternative splicings.
To our knowledge, this is the first integrated assessment of specific alternative active transport policies, and one of the first uses of SDM to integrate health, social, and environmental outcomes of urban policies.
Moreover, quantitative real-time RT-PCR appears to be useful for analyses of relationships between the appearance of specific alternative splicing variants and different kinds of physiological, metabolic and developmental processes as well as responses to environmental changes.
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While Frank finds these ideas "bracing," he's disheartened by the lack of "specific alternatives" in Smolin's view.
By the empirical testing of specific alternatives, side by side, at the pharmacological, physiological, individual bee and colony level, it will be possible to step forward, one step at a time, toward progressively less toxic methods of controlling insect pests.
Another possible explanation for the discrepancies is that there is a high degree of tissue specific alternative splicing of the TCF7L2 gene [ 42– 42].
This switch in PTB paralogs is responsible for switching a subset of neuronal specific alternative splicing events [24], [25].
Genes with significant Exon-Tissue interaction (ED effect) are said to show signs of tissue specific alternative splicing p-value<0.001 p-value<0.001
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