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Another potential limitation is the use of single outcome items as cluster variables.
A growing number of single outcome risk scores for identification of people at risk for either future CVD (6, 7), type 2 diabetes (8, 9), or CKD (10) have been developed.
While, generally, no effect was observed at intermediate levels of exposures or longer distances, the extent to which this is a product of the small size of the study, misclassification in (or the crude nature of) the exposure, or even the use of single outcome self-reported measure is not clear.
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Sudhin A. Shah, Ph.D. / Jason B. Carmel, M.D., Ph.D. Efficacy and Negative Outcome Profile of Single Event Multilevel Onabotulinum Toxin.
A cost effectiveness analysis of the three regimens would have required specification of a single outcome as reflecting the objective of the treatments.
Another advocate of "prospective hindsight", the academic Karl Weick, argues that it works because of a cognitive quirk: we find it easier to imagine the detailed causes of a single outcome than causes of multiple outcomes.
The context of this study is a class of observational studies where we hope to identify predictors of a single outcome from within a range of 20-40 possiblexplanatoryry variables.
The univariate model for the square root of ADAScog explains 63% of the variance, and the prediction error of a single outcome in cross-validation is 0.67.
But there were not enough women with enhanced M.R.I.s to draw definitive conclusions about the risk of any single outcome.
Previous wellness efforts have focused on measurement of a single outcome or many outcomes in isolation.
In the first experiment, we apply Proclus to the preprocessed dataset and aim for subspace clusters that contain mainly patients of a single outcome.
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