While the multiple comparisons of the 84 planned sign tests with an alpha of 0.05 would be expected to identify approximately 4 positive results (1/20) by chance, the probability of this occurring by chance in all 3 ratings of a single endpoint is 1/(20*20*20), or 1/8000.
This approach will make it possible to go beyond the calculation of a single endpoint for each subject, and to translate the trial findings into definitions of effectiveness and outcomes that will be relevant to the ongoing debate concerning how best to relate the benefits of such medications to their costs.
The decrease in Soret band absorbance at 415 nm that occurs when heme interacts with artemisinin was selected as a simple primary readout of a single endpoint assay, rather than using absorption spectra or focusing on the peak that occurs at 476 nm.
Co-expression of NCS-1 did not alter the basal phosphorylation state of NFAT-GFP compared with control transfected cells nor did it exert a detectable effect on NFAT-GFP dephosphorylation/nuclear translocation after sustained elevation of [Ca2+]i during single endpoint and acute time course analyses.
I envision a web that in the next few years enables users to orchestrate a variety of services from any single endpoint.
While understanding how the single endpoint of in vitro inhibition compared to in vivo change is a standard part of the integrated preclinical risk assessment, 70 now in silico predictions allow assessment of the combined effects on multiple molecular targets.
A world wide directory will allow developers to use a single endpoint regardless of the user's location.
Unfortunately, all preterm births or stillbirths have usually been defined as a single endpoint, regardless of etiology, for epidemiological purposes.
Similarly, antibody based fluorescence imaging can only provide single endpoint measurements of the cell because they require cell fixation and permeabilization, which render the cells nonviable.
However, the sequence of events that led to gliosis at the ventricle surface and ventriculomegaly could not be deduced from this single endpoint analysis of lateral ventricle volume and surface histology.
