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The ethical committee of the University Hospital Würzburg has determined that for analysis and publication of single center case series this informed consent is sufficient and no specific review of retrospective data analysis projects are required.
A large number of single center and multicenter trials have been reported that indicate the accuracy of several different methods, and the largest prospective randomized trial of SLN biopsy versus ALND, conducted by the National Surgical Adjuvant Breast and Bowel Project (NSABP), completed accrual last year.
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The quality of RCTs conducted in multiple centers was superior to those of single centers regarding random sequence generation, allocation concealment, and blinding.
Blunt abdominal aortic injury (BAAI) is very rare, and current literature is limited to case series of single-center experience.
There are notable examples in neonatology where results from multi-center trials have contradicted results of single-center studies.
In this paper we discuss issues around external generalizability of single-center studies, and methodological issues that may cause bias.
However, the great majority of the literature is composed of retrospective observational data, often in the form of single-center studies with relatively small numbers of subjects.
The results of single-center studies have shown that surgical intervention for lumbar spinal stenosis yielded comparable health-related quality of life (HRQoL) improvement to total joint arthroplasty (TJA).
To present the clinical appearance, differential diagnosis, long-term follow-up, and the surgical result of single-center experience with female urethral polyps presenting as an interlabial mass, and to report the common causes of interlabial masses in infants.
The variability also highlights the limited external validity of single-center studies.
A number of single-center prospective cohort studies that enrolled patients at risk for ARDS have identified risk factors for the development of ARDS.
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