Overall, comparing with other extrusion pretreatments (Table 2), the ATSE pretreatment method exhibits several desirable characteristics: high sugar yield, no need of severe size-reduction prior to the extrusion, relatively low temperature (99°C) and no extra heating needed.
The Conover and Munch (2002) harvest experiment was designed to measure the rate of evolution of these traits in response to severe size selection imposed by removing the largest 90% or the smallest 90% of the population each generation after the fish had grown to adult size.
The NEMD method is often the method of choice for studies of nanomaterials, while for bulk thermal conductivity, particularly that of high conductivity materials, the equilibrium method is typically preferred because of less severe size effects.
Subgroups were planned a priori for age, gender, socioeconomic status, type of illness (mild or severe), size of absolute effect and severity of side effects.
To overcome the severe size limitation of the rAAV for carrying exogenous DNA, an enhanced green fluorescent protein (EGFP -Luciferase fusion gEGFP -Luciferaseboth a selectable marker and gene expression reporter.
With this sample size, an analysis performed in the subgroup of severe patients whose size was expected to be half the targeted sample size (ie, 180 patients) could still achieve 75% power to show a difference of 0.35 mm versus placebo.
Independent predictors of severe disease (in diminishing size of effect) were low weight on admission, low gestation at birth, low NPA IFN-γ and NPA SP. Nasal airway sampling appears to be a useful surrogate for distal airway sampling since concentrations of IFN-γ, SP, IL-9 and viral load in NPA correlate with the same in BAL.
Secondly, the relatively small sample size of severe stable angina patients might aggregate the ceiling effect.
As a result, the mothers were grouped according to the severity of their child's condition: mild and moderate/severe (moderate and severe conditions were collapsed together due to the small sample size of severe cases; see Results for details of this process).
If the potential mediator showed statistical significance with both severe maternal morbidity and PTSD symptoms, multivariable logistic regression models were developed to see if the effect size of severe maternal morbidity on PTSD symptoms disappeared (fully mediated) or were reduced (partially mediated) by adding the potential mediator.
The authors concluded that the cause of this severe population size crash is a synergism between human activities, including hunting, habitat loss due to deforestation and disease (see also [ 51]) and strongly emphasized the need for effective and immediate conservation actions in order to ensure the long-term survival of gorilla populations.
