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One of the main challenges in the molecularly imprinted polymers (MIP) field is the proper MIP design for water-soluble compounds because of appearance of serious drawbacks in polar solvents and insolubility of those compounds in non-polar solvents which are commonly used for MIP synthesis.
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One of the most serious drawbacks of barrier screws is that they are more susceptible to solid bed plugging; severe plugging results in process instabilities (surging).
This caused an unequal age distribution in the different groups and was therefore potentially one of the most serious drawbacks of this study.
Nevertheless, one of the most serious drawbacks upon using hydrocarbon-rich fuel gas is the deposition of carbon or carbon filament formation on the electrode, blocking gas diffusion at the catalytically active triple phase boundary anode/electrolyte/fuel by coking, and in parallel inducing mechanical damage via carbon filament formation and nickel "dusting".
All current models, such as those of Switzerland and Norway, have serious drawbacks.
Duchenne is treated primarily with steroids and artificial ventilation machines, both of which have serious drawbacks.
A number of novel imaging modalities have been developed but they are still in the initial stages of development and serious drawbacks obstruct them from offering their benefits to the medical field.
The complexity of automation and/or the lack of sensitivity are still serious drawbacks in these methods.
(Given the work's unfamiliarity, a shortage of printed librettos and a lack of overhead titles were serious drawbacks here).
The serious drawbacks of these methods are low efficiency, disposal of waste, low sensitivity, etc. [18, 19].
This is mainly because semiparametric regression reduces the high risk of misspecification relating to a fully parametric model and avoids some serious drawbacks of fully nonparametric methods.
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