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This study was designed to evaluate the efficacy and tolerability of sequential administration of irinotecan and cisplatin and then docetaxel in patients with advanced non-small cell lung cancer (NSCLC).
Scores obtained from the STAI-S and STAI-T correlate positively with each other, particularly in the case of sequential administration.
One preclinical study assessed the effects of sequential administration of pemetrexed and erlotinib, and showed cytotoxic synergism in both mutant and wild-type EGFR cell lines [ 12].
The objective of sequential administration is to limit the administration of NO to the inspiratory phase so that the bolus effect is avoided.
Although, synergies were undeniably proven using combinations in multiple ratios, an assessment of sequential administration of different treatments was not done.
In contrast, the use of sequential administration of gemcitabine and pemetrexed partially prevented the reduction of cytotoxic activity by simultaneous administration of deoxycytidine in both cell lines.
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We may hypothesize that the long-term effects of furosemide depend on its acute and immediate inhibition on Henle's loop, unveiling the activity of nephron proximal tubules, which, as an additive effect of sequential administrations, is responsible of the long-term effects observed.
Our study shows that intravenous administration of furosemide, even at low doses, in patients with relatively normal renal function, induces an immediate subverting of both normal urinary excretion rate and concentration of main electrolytes, which commences very rapidly, and may have subsequent long-term effects as an additive result of sequential administrations.
In addition, the use of a BsAb eliminates the need for sequential administration of two separate mAbs, saving the patient's time.
The Opti-NO (Taema, Anthony, France) is a system designed for sequential administration of NO into the downstream of the ventilator [ 13].
The aim of our study was to look at changes in human tumours exposed to sequential administration of sunitinib and everolimus to provide information that could serve for clinical trials aiming at delaying tumour PG in RCC patients.
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CEO of Professional Science Editing for Scientists @ prosciediting.com