Pregnant women carrying a live fetus, of any parity and gestational age, booked for antenatal care at one of the selected centers, and capable of answering an oral questionnaire were considered eligible to participate.
In April 2016, a cover letter was sent by e-mail to the chairs of the selected centers explaining the rationale and objective of the survey, and providing a personalized link to access the questionnaire and instructions on how to complete it.
As a representative, the widely used k-means clustering begins with an initial set of randomly selected centers and then iteratively refines this set to decrease the sum of the squares distances.
Then GA changes the locations of the initially selected centers to find the optimum positions of centers from the whole space of scores matrix, in order to obtain highest prediction ability.
The results of protocols at selected centers that offer gene therapy, photodynamic therapy, hyperthermic chemotherapeutic perfusion, and intrapleural chemokines will be discussed, as well as newer preclinical approaches that base targeted therapies on novel molecular findings.
Yet, despite documented benefits in selected centers of excellence, only two regional programs have been described, both almost 20 years ago (4, 11).
A substantial proportion of patients with type 1 diabetes will develop diabetic nephropathy years after onset of diabetes, although studies from selected centers suggest a declining incidence (6, 7).
The use of T-cell therapy in cancer as well as for prophylaxis and treatment of infectious diseases following HSCT in selected centers around the globe is rapidly expanding, and immunotherapy was highlighted as the breakthrough for cancer in 2013.
Further, the level of satisfaction for patients who had been referred to the facility by their doctor was significantly lower compared to that of patients who were recommended by former patients or who responded "Other" and selected the facility using sources other than the pre-specified ones, most probably using the Internet, or guided by the reputation of the selected center.
Geographic representativeness was achieved by an unbiased selection of the specialized care centers throughout the whole country, and a random enrollment of investigators in each selected center.
