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These models have been optimized and constructed in close relation and guidance of relevant experiments.
We have introduced methods for retrieval of relevant experiments, given a sample experiment as a query.
The probabilistic nature of the model allows for a precise formulation of retrieval, in which the model is queried with the differential expression in gene sets of an experiment and it returns a ranked list of relevant experiments.
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But complex strategies can be employed, including comparing the output of subsystems of a simulation to relevant experiments (Parker, forthcoming; Oberkampf and Roy 2010).
SL contributed to formulation of study design, conducted some of the relevant experiments, analysed the data, and contributed to writing and critical appraisal of the manuscript.
KD contributed to formulation of study design, conducted some of the relevant experiments, recruited the patients, analysed the data, and contributed to writing and critical appraisal of the manuscript.
A total of six relevant experiments were obtained and five of them (five experimental designs) were explicitly dedicated to OSCC, whereas one was available for head and neck squamous cell carcinoma (HNSCC).
Given the damage that iron-mediated OH radical can create, the question arises as to whether appropriate chelators can inhibit this by inhibiting the production of OH, and while the answer is 'yes' the interpretation of the relevant experiments is not always as clear cut as one would wish [ 43].
For the meta-analysis, the most common problems resulting in exclusion of otherwise relevant experiments were issues with the experimental design, and the absence of statistics (variances and replicates).
But the comfort of 100% certainty will not be available in the foreseeable future, leaving us with the challenge of designing relevant experiments and test systems upon which to base "logical" policy in risk management.
But it was nice to see some of the relevant experiments reported on in the Times, even if the explanations were left out.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com