No long-term selection over multiple generations for adaptation to captive breeding has been imposed on the breeders, a factor that has led in other breeding programs to reduced success of released offspring back into nature (Williams and Hoffman 2009).
In light of the reduced success of previous attempts to correct genetic alterations in pancreatic cancer through gene therapy, these considerations also highlight the possibility that early intervention against stress-induced proteins may be more beneficial for the management of this cancer and likely other malignancies, which are known to associate with Kras mutations.
Moreover, the overrepresentation of selfing genotypes may be reduced with time since colonization as a result of inbreeding depression [ 14]: the reduced success of inbred progeny due to the expression of genetic load (i.e. recessive deleterious alleles).
As infection with mucoid isolates of P. aeruginosa is associated with reduced success of eradication treatment in patients with new infection [ 57, 58] and a worse prognosis for patients with chronic lung infection [ 3, 59], it might be expected that a differential response against mucoid isolates might impact PEx outcomes.
These findings are in line with earlier modelling that suggests that cub productivity (recruitment of susceptibles) is a major reason for the reduced success of vaccination, and that this could in the future be overcome by the use of fertility control [ 29].
Structural and biochemical changes in host plant cells, in particular the accumulation of PR proteins with antimicrobial properties, are considered responsible for the reduced success of subsequent infections (van Loon and van Strien 1999).
To determine if the antagonistic interactions observed in vitro correlate with reduced success of sub-colonies in vivo, we perform sub-colony experiments composed of novel ant-fungus-bacterium pairings in which there is antagonism from one, both, or none of the symbionts (Fig. 1).
Knee contractures, present either before or after surgery, are associated with reduced success of TKA [ 18].
The reduced success of the EPIC approach for SNP discovery is most likely due to the duplicated nature of the salmonid genome.
