This makes studies of older designs sometimes of questionable applicability to those currently being sold.
Certainly, PI control of study design would seem to be of questionable applicability in cases where the design of the study is determined in advance by explicit regulatory agency direction.
However, health care providers are often faced with a paucity of evidence for specific patient groups such as children and youth, and thus must rely on evidence of questionable applicability as the basis for their health care decisions.
At the same time, a number of implementation challenges have been identified by multiple researchers and organizations, including the complexity of manufacturing process controls, the questionable applicability of conventional NDI (non-destructive inspection) methods and the lack of industry standards and design allowables, etc.
Commonly identified flaws in reliability studies are the exclusive use of healthy individuals, questionable applicability in clinical practice, low sample size, the absence of a protocol and the use of inadequate statistics [ 18].
Commonly identified flaws in these reliability studies were low sample size, unclear selection criteria, the use of only healthy individuals, use of inadequate reliability statistics, the absence of a protocol, and questionable applicability in clinical practice.
This unclear status and the subsequent questionable applicability of existing federal guidelines for human subject research pose an ethical concern.
Given that the c/K subunits are short, highly diverged integral membrane proteins, we believe that any phylogenetic reconstruction and testing would produce, at best, unreliable results (not in the least due to the questionable applicability of the canonical evolutionary models to transmembrane segments).
Considered alone, however, animal models of breast cancer progression will always have questionable applicability to human disease.
To date, the literature has emphasized the sharing of biological data, data originating from a biological sample, which has questionable applicability to the parameters necessary for consenting to secondary use of non-biological data (Brakewood and Poldrack 2013).
Most research on IBS has been performed on referred patients with IBS with questionable applicability in a general practice setting.
