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One of the main criticisms made by the Neuberger review was the lack of prospective testing of the LCP.
Two gene signatures, the 70-gene signature which has been studied in this paper, and the recurrence score [ 21] have reached the final step of prospective testing in the MINDACT (Microarray in Node Negative Disease May Avoid Chemotherapy) and TAILORx trials, respectively.
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The Collaboratory for the Study of Earthquake Prediction (CSEP) instead provides us an opportunity for prospective testing of the Coulomb hypothesis.
We stress that it should not be assumed that the results in Tables 1 6 reflect the relative value of the models for prospective testing.
Amid resurgence in earthquake predictability research, the working group on Regional Earthquake Likelihood Models (RELM) established a facility for prospective testing of scientific earthquake predictions in California (Field, 2007 and reference therein).
Morphoproteomics can potentially identify targeted combinations of drugs appropriate for prospective testing [9].
Second, study of idiopathic RBD allows prospective testing of other predictive markers of neurodegeneration.
With the development of the PAM50 assay, prospective testing of this classification by independent groups will determine its prognostic and predictive power and clinical utility above and beyond the clinicopathological parameters currently available.
Prospective testing of these plasma proteins as markers of response to chemotherapy within clinical trials, comparing responders to non-responders, is now required.
As the Inno-Lia is a confirmatory HIV test, it permits prospective testing of all newly diagnosed patients and notification of the results to the respective health authority, which may then periodically calculate the proportion of recent infections among the notified new cases or determine the incidence if the total number of HIV tests performed is also known.
Prospective testing of a parameter on an independent set of patients in a multicentre setting is the ultimate test a parameter has to go through before reaching the level of evidence (LOE) type I according to the Tumor Marker Utility Grading Scale as introduced by Hayes et al (1996).
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