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Sample size calculations were described in 60% (43/73) of primary reports; clustering was accounted for in 47% (20/43) of these.
More than 90% of respondents were corresponding authors of clinical trials (275 (87%) of primary reports and 20 (6%) of secondary reports of clinical trials), and 22 (7%) were corresponding authors of prospective observational studies.
A previous meta-analysis reported no overall association between alcohol consumption and ovarian carcinoma, but did find a 6% increased risk of mucinous ovarian carcinomas (95% CI, 1.01, 1.12, n=581) with each increase in intake of 10 g/day alcohol using continuous estimates obtained from authors of primary reports [ 37].
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Table 1 provides information on the general characteristics of the primary reports of randomised trials as described in the published article.
We contacted authors of the primary reports to request any unpublished data.
In the context of the primary report of ON1 in Ontario, Canada (3 ), and the GenBank entry from Japan, our data suggest worldwide emergence of ON1.
Table 3 provides verbatim examples of incomplete reporting of descriptions of interventions from the primary reports.
Most of the RCT reports were primary reports of single RCTs (73.8%; Group R1).
Of the 73 primary reports, 51 included a statistician or other quantitative methodologist as a co-author.
In the present study, MHC2TA genotype and allele frequencies of the population differed statistically significantly from those of the primary report [ 12] (Table 3).
Sample 93 primary reports of randomised trials published in BMC-series medical journals in 2012.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com