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We emphasise, however, the importance of assessing each case on its merits by including pilot studies and the generation of preliminary data to develop a specific strategy for the material at hand.
Unfortunately, many GWAS findings lack follow-up owing to the sheer number of loci and genes identified or lack of preliminary data to warrant an in-depth investigation of individual gene candidates.
The selection of the other study medications from the ten classes of available agents to add to metformin was predicated on the most commonly used approved combinations and the availability of preliminary data to support their glycemia-lowering effectiveness, safety, and tolerability.
(2) Existence of preliminary data to rationalise trials in humans: Epidemiologic data, that is, hypotheses-generating associations, have not accurately predicted prospective cancer preventive outcomes to date with sufficient certainty to justify large-scale, high-cost trials with a cancer end-point (Meyskens and Szabo, 2005).
The rapid release of preliminary data to the research community while enabling their producers to obtain credit through citation is a growing trend with the BGI, and the wider research community, where the speed of data production far outstrips the ability of researchers to analyze and write up their findings.
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First, design bias – the process of using preliminary data to design studies with a high likelihood of being positive – partly accounts for the remarkably high percentage of trials sponsored by industry that yield results favoring the sponsored drug.
Despite the fact that this study was carried out on a very small number of samples, it provides preliminary data to reflect the actual situation on the European market.
We are currently pursuing the notion that Gαq stimulates the translation of Fhit as we have preliminary data to suggest that the up-regulation of Fhit is blocked by cycloheximide.
The aim of this study was to obtain preliminary data to determine the effect of yoga on women with BCRL.
Although we acknowledge that this methodology would give a higher resolution data set, the primary aim of this study was to provide preliminary data to inform future work, and assessment of telomere length in PBLs has been the approach used by others in this field [36,37].
This work is aimed to reduce the arsenic content in complex concentrates of galena and to generate preliminary data to allow us to conduct further studies to understand the complex behavior of the bioleaching process.
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