The state of the art of current research does not give precise indications of the damage window for Pb-related neurodevelopmental impacts.
First, we were not able to accurately assess the benefit/risk ratio of contrast-enhanced CT since precise indications of CT and subsequent therapeutic changes were hazardous to extract retrospectively from patients' files.
Of note, the precise indications for RRT were not provided.
Fortunately, O'Neill was a copious writer of stage directions, sometimes giving long, meticulous descriptions of his characters as they are introduced and precise indications of both actions and their emotional inflection.
Both the limits and strengths suggest the need of further studies to define a favourable cost-benefit profile of the procedure and precise indications for its application.
Recent studies emphasise the accuracy of diagnosis, classification and precise indications for surgery [1, 2, 3].
The gathered information about advantages and disadvantages can be combined with the study of S-curves and with a full-scale failure analysis to provide precise indications about the potential of development for a given technology.
Significant debate still exists concerning the precise indications and efficacy of NIV in this patient population [ 30] without any mention of the problem of impaired airway secretion.
Since IVR is an expensive treatment and carries the risk of complications such as endophthalmitis, establishing precise indications for IVR is very important for the best benefit/risk ratio and cost performance of this therapy.
As we do not know the precise indications for the choice of these interventions, the appropriateness cannot be analyzed.
