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The ReDo project has drawn up a list of the six most promising drugs based on their low toxicity, plausible mechanism of action and strong evidence of potential efficacy in humans.
In clinical trials for novel interventions, functional end points typically are included in the assessment of potential efficacy.
Frequently, encouraging signals of potential efficacy for novel agents in early phase clinical trials have been followed by disappointing failures in larger phase III trials, raising the valid question of how drug development can be optimized for patients with pancreatic adenocarcinoma and biliary tract malignancies.
When really good trial data are not available but patient need goes on, reliable evidence of safety and early hints of potential efficacy may be enough to give something a try.
Secondary objectives included assessment of potential efficacy and biological activity and exploration of candidate biomarkers.
Signals of potential efficacy were observed in MRSS, FVC and patient-derived quality of life indices.
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The results of our study provide additional evidence of the potential efficacy of CpG and IL-15 and how it may improve vaccine approaches against cancer and infectious diseases.
Given the causal relation between HPV infection and OPSCC, clinical evaluation of the potential efficacy of HPV vaccines for reducing the incidence of HPV-associated OPSCC is warranted.
A recent systematic review and meta-analysis of 19 randomised and 29 non-randomised controlled studies provided evidence of the potential efficacy of walking interventions [ 6].
Traditionally, foundations make grants based on their assessment of the potential efficacy of a program.
Although bispecific antibodies (bsAbs) are not new, they are coming to the forefront as our knowledge of the potential efficacy of antibody-based therapeutics expands.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com