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Exact(4)
The mapped concept gets integrated into the ontology enabling retrieval of possible hits and direct hits by crawling up and down the hierarchy.
In addition to returning the data directly matching the search criteria, OntoSearch also identifies a pool of possible hits by taking into consideration incomplete metadata annotation.
In fact, while the potential intrinsic error rate of every rule based on SAs remains unaltered, since all the non-mutagens should be still present (that means new FPs generated), the number of possible hits (caught FNs) drastically decreases because just a few mutagens are left.
Among the list of possible hits (step f), the sc-PDB entries were ranked by decreasing similarity to 1aux and corresponding proteins were ranked (step g) according to a Receiver Operating Characteristic (ROC) classifying scheme [40] from the statistically most similar (Pim-1 kinase) to the least similar (panthothenate synthase).
Similar(55)
The OntoSearch algorithm crawls down the hierarchy for direct hits and crawls up for possible hits.
The identification of direct and possible hits in the cases of brain regions has to take into account multiple dimensions when crawling up and down each hierarchy.
The results are returned in two separate sets of direct and possible hits.
In this mode, CLARK stops querying k-mers for an object as soon as there is at least one target that collects at least half of the total possible hits.
Mass spectrometry data was analysed manually using Qual Browser version 2.0.7 (Thermo Fischer Scientific Inc .. Peak lists of different retention time segments were extracted and possible hits of lipids were identified by applying tools of the lipid maps database (http://www.lipidmaps.org).org
In contrast, querying for 'spangled skimmer' (a type of dragon fly) returns 30 neurons from dragon flies of unspecified type as possible hits.
The use of high-throughput screening techniques to identify hits that act as i-PPIs in conjunction with the development of techniques to optimize the possible hits to discover proper leads (hit-to-lead techniques) is a matter not fully solved yet.
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