Sentence examples for of perk from inspiring English sources

Thus, genetic variation that results either in alteration of PERK protein function or significant changes in the amount of PERK would perturb several crucial stress-response pathways.

Disruption of the PERK-BiP complex results in dimerization, autophosphorylation and activation of the kinase domain of PERK.

With normal levels of pERK and pCREB restored, the mice's behavior returned to normal.

The level of pERK is higher in CFA and IS treated groups.

Similarly, eIF2α phosphorylation (indicative of PERK activation) was elevated when Sec61β was knocked down (Fig. 3A).

5-HMF could enhance the effects of PERK knockdown, protecting the cells against the GalN/TNF-α insult.

Salubrinal, an eIF2α inhibitor, or overexpression of dominant negative mutants of PERK or eIF2α, effectively restored RES-induced cell cycle arrest, underscoring the important role of PERK/eIF2α branch of UPR in RES-induced inhibition of cell proliferation.

Experiments using PERK- and GCN2-knockout cells demonstrated dual contribution of PERK and GCN2 to nsPEF-induced eIF2α phosphorylation.

Activation of pERK correlated with high levels of G3 expression.

Validation of Perk down-regulation using RT-PCR showed non-detectable levels of Perk in Hnf6 Tg animals, with much higher levels in WT pancreata (Figure 3).

Thus the generation of PERK conditional knock out mice in the mammary gland epithelium will aid in investigating the function of PERK in this tissue.