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To address the uncertainty, we examine the sensitivity of our unbiased cCFR estimate to different means (6 14 days) and variances (9 159 days2).
Despite a need to further clarify heterogeneous risks of death for the S-OIV pandemic, early assessment of virulence by means of our unbiased cCFR estimator is useful for informing policy makers and the general public about the potential severity of an infectious disease (of course, one needs to ensure an understanding of the above mentioned bias among non-experts).
However, the ZNF131 motif was not identified in any of our unbiased motif analyses.
Additionally, we have revised the Introduction to include a more detailed description of the literature on the physiological effects of hydroxyurea and serum starvation, which we hope will provide better context for readers to interpret the results of our unbiased, system‐wide analysis.
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As of 2013, our unbiased CO survey covers nearly the entire Northern sky with sampling of 1/4-deg or better; a recent coverage map is available here.
The high rate of identified target genes supports our unbiased approach and shows the potency of this method for finding novel target genes.
Our unbiased estimation of the cCFR does not address all sources of error in data (e.g. underdiagnosis of infected individuals) and we summarize the relevant issues in the discussion.
Our unbiased analysis of differentially expressed genes following MEKi supports the effect of Ras/MAPK pathway inhibition on immune cell function, but also highlights that other pathways are activated in response to reduced MEK activity, which may be further enhanced by α-OX-40/4-1BB α-OX-40/4-1BB α-OX-40/4-1BB α-OX-40/4-1BB
Our unbiased mapping of Pax8 binding sites along the rat genome has identified a large number of DNA sequences that are occupied in living thyrocytes.
Photosynthesis and related biochemical processes were recurrently identified in our unbiased search of affected pathways (Additional files 2, 3 and 4).
As suggested by individual images, our unbiased analysis of 53 roots (8547 reconstructed cells) revealed that the number of cells expressing FLC-Venus decreased quantitatively with the duration of cold exposure.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com