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Berger points out that Puccini, despite his popularity, creates discomfort in this hyper-stylized, ironic age, because he deals in direct emotion, avoids ideology and moralism, and often favors characters "of no major consequence," except insofar as they mirror the audience.
The effects of modulating the ER system in the breast, at one time or another, have been dismissed because the effects are small or believed to be of no major consequence.
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Overexpression of wild-type RFP2, detectable in western blot as a main protein band of ∼74 kDa plus additional weak bands known to be the auto-ubiquitinated forms of the ligase (34), had no major consequences on the degradation of V247M mutant.
The oldest tin mines were those in Cornwall, which were worked at least as early as Phoenician times but are no longer of major consequence, and Spain.
It contains little new to the attentive observer and none of that is of major consequence.
Their payroll and the contract status of their players make any trades of major consequence unlikely, and if they cannot get Webber or another all-N.B.A.-caliber big man, they will sign Houston to a lucrative, long-term deal.
A more skilled operator could have worked out a compromise, but in 1943 Wallace went public with inflammatory charges that Jones's "obstructionist tactics . . . have been of major consequence in this job of waging total war".
We would not expect such recession to be of major consequence, however, and it may well be out of the way by around the middle of the month.
It is of major consequence to the NHL, as it would be for any league.
But, since 2000, nation-states of major consequence — Russia, Hungary, Thailand, and the Philippines among them — have gone in the opposite, authoritarian direction.
"I don't think there's any position of major consequence that the editorial page has taken over the years that I would not be a believer in," he said.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com