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Our data support the notion of multiple steps of structural reconfiguration required for efficient target engagement.
Unlike single footprints which have been found before, tyrannosaur trackways are made up of multiple steps, revealing the length of stride and other features of the animal's movement.
Typical proteomic study consists of a string of multiple steps each of which can be validated by different orthogonal methods.
We generalise the coarse Ricci curvature method of Ollivier by considering the coarse Ricci curvature of multiple steps in the Markov chain.
We prove a recursive lower bound on the coarse Ricci curvature of multiple steps in the Markov chain, making our method broadly applicable.
The proof system consists of axioms about individual protocol actions and inference rules that yield assertions about protocols composed of multiple steps.
"Even evolutionary changes that seem to be very sudden and dramatic may typically require a series of multiple steps drawn out over much longer periods of time than meets the eye," Lenski said.
The unique fragmentation consisting of multiple steps is induced by a cyclization reaction of b ions, the mechanism of which has been probed by experiments of N-acetylation, MSn, rearranged-ion design, and activation-time adjustment.
Dashed arrows show involvement of multiple steps.
Almost all lignans are still mainly produced by extraction from plant materials because of their complex biosynthesis pathway and the involvement of multiple steps and enzymes.
However, these synthetic methods were unsuitable to industrial scale-up mainly due to the involvement of multiple steps and dangerous chemicals such as lithium aluminium hydride (LAH).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com