CD40 signalling results in the activation of multiple signalling cascades including signal transducers and activators of transcription factor 3 (STAT3)(Hanissian & Geha, 1997).
Eed deficiency also causes induction of multiple signalling pathways in chondrocytes.
This signalling route is distinct from the better-characterized, traditional EGFR pathway that involves transduction of mitogenic signals through activation of multiple signalling cascades.
Compared with the substantial research efforts aimed at clarifying the evolution of multiple sexual signals [ 2- 4], the cause of multiple signalling in agonistic communication has remained neglected.
For most applications, the environment leads to the arrival of multiple signals corresponding to emitted signal, signals which are scattered by the objects, and noise.
These data indicate that chemoattractant receptors induce chemokine production in HMC-1 cells with a selectivity that depends on the level of receptor expression, the length of their signaling time, and the synergistic interaction of multiple signaling pathways, including extracellular signal-regulated kinase phosphorylation, sustained Ca(2+) mobilization and NFAT activation.
The results suggest that yuanhuacine induced apoptosis via the regulation of multiple signaling pathways toward an increment of death signals.
Results showed that yuanhuacine induced apoptosis via the regulation of multiple signaling pathways toward an increment of death signals.
The traditional receiver operating characteristic analysis was extended for single-signal detection and classification of multiple signals [6].
Cbl inactivation, which rescues the developmental defect in Vav1-/ thymocytes, thus enhanced activities of multiple signaling molecules, including the early TCR-mediated signal molecule Lck, in addition to enhancing normally Vav1-dependent downstream events.
However, there is experimental evidence of tumors showing dysregulation of multiple signaling pathways that interfere with cytokine signals [ 5, 6].
