Sentence examples for of multiple signalling networks from inspiring English sources
The contribution of multiple signalling networks to tumorigenesis also accounts for the limited responses seen with MEK inhibitors alone.
These changes collectively demonstrate that the regulation of multiple signaling networks is corrupted in CD22ΔE12-Tg CD22ΔE12-Tg
The ultimate cellular response reflects the input of multiple signaling networks and does not result from a key "molecular target" or dedicated signaling pathway.
Second, they imply that combined inhibition of multiple signaling networks in human cancer cells might be required in order to meaningfully alter their natural progression.
In light of the balance and interplay of multiple signaling networks involved in various signaling contexts of different cell type and stimuli, it is not surprising that Ras/ERK regulation is complex.
The wealth of Ras activators and effectors identified in mammalian cells places the Ras proteins at the center of multiple signaling networks critical for normal cellular development and homeostasis and for pathological processes such as cancer [ 1- 4, 7- 9].
A general coregulator such as Gro/TLE makes a perfect integrator of inputs from RTK signal transduction cascades with multiple signalling networks.
GO-STRING analysis revealed multiple signalling networks activated by doxorubicin and etoposide and supports the complexity of the cellular response to Top2 poisons.
Multiple signaling networks and feedback loops "downstream" of KRAS have been described that respond to obesogenic diets.
The inner leaflet of the plasma membrane serves as a central assembly and diffusion platform on which multiple signaling networks form and conduct their functions as needed.
Accumulative genetic changes within malignant plasma cells, together with MM interplay with the bone marrow microenvironment (BMME), potentiate disease progression by promoting the deregulation of multiple signal transduction networks, one of which is the Ras/MAPK pathway.
