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Moreover, arrest of multiple signal pathways favors the overcome of resistance that commonly occurs in single-targeting monotherapy[28].
These results indicate that HYF127c/Cu induces changes of multiple signal pathways in cancer cells.
Therefore, SLC25A1 likely provides a nodal point at the cross-road of multiple signal pathways altered by mutant p53.
C-Src, a non-receptor tyrosine kinase is a critical link of multiple signal pathways that regulate proliferation, invasion, survival, metastasis, and angiogenesis.
Time series of gene expression often exhibit periodic behavior under the influence of multiple signal pathways, and are represented by a model that incorporates multiple harmonics and noise.
This is not only of particular interest due to the importance of oxidative stress in PD (for examples and reviews see Gotz et al, 1990; Jenner, 1991; Smeyne & Smeyne, 2013; Zhou et al, 2008), but may also represent a novel mechanism by which the activity of multiple signal pathways may be enhanced.
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Despite data showing activation of multiple signalling pathways upon RAGE ligation, only little is known about proximal signalling events directly downstream of the receptor [ 11, 12].
Eed deficiency also causes induction of multiple signalling pathways in chondrocytes.
FAK promotes cell migration via the activation of multiple signaling pathways involving kinases, or by phosphorylation of other FA components26.
Powers MV, Workman P. Targeting of multiple signalling pathways by heat shock protein 90 molecular chaperone inhibitors.
"...We investigated whether the diverse experimental evidence can be unified by creating a spatial, mechanistic model of multiple signaling pathways in hippocampal CA1 neurons.
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