Studies on effects of drugs of abuse on HIV infection have been problematic to conduct, primarily because of high variability in drug-usage patterns, length of use and multidrug use, as well as differences in nutritional status and access to medical care.
Nancollas explained that the expertise that developed around leprosy in the 1980s – at the time of a massive push against the disease through the use of multidrug therapy – is being lost as experts retire.
These control efforts, which are the focus of antimalarial strategies established by the WHO, include the dissemination of insecticide-treated netting, the provision of prophylactic drugs to pregnant women, and earlier and more effective treatment of clinical cases, preferably through the use of multidrug "combination therapy" in order to attack drug-resistant parasites.
Although it is not clear whether CC-3052 co-treatment can improve the efficacy of multidrug TB therapy, the use of a host-targeted drug has a considerable benefit because Mtb cannot develop genotypic resistance to a drug that targets host function.
The use of multidrug combinations is a given paradigm in the treatment of tuberculosis.
However, the use of multidrug therapies is very challenging, due to a lack of understanding of the mechanisms of drug interactions.
In other studies, lipid nanocapsules loaded etoposide were synthesized due to their hypothesized reversal of multidrug resistance by the use of P-gp inhibitory surfactants during formulation.
Seeking to eliminate leprosy by the year 2000, a campaign by the World Health Organization was based on widespread provision and use of multidrug therapy (MDT) to control infection and reduce transmission.
In this study, although infection control policies and management practices are generally appropriate in Italian ICUs, certain aspects, such as the extensive use of multidrug empirical regimens and the inappropriate antimicrobial dosing, deserve careful management and closer investigation.
Indeed, in most patients for which blood pressure targets are difficult to achieve the use of multidrug combinations will often produce greater blood pressure reduction at lower doses of the component agents, resulting in fewer adverse events [ 47, 48].
