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The progressive accumulation of molecular damage is a universal characteristic of ageing [1 3].
Among the main causative agents of damage, such as reactive oxygen species (ROS), nutritional metabolites and biochemical infidelity, the nutritional metabolites are an important source of molecular damage.
Each recovered sequence showed some signs of molecular damage in the form of DNA fragmentation and type 2 miscoding lesions to a lesser extent, indicating authentic ancient DNA.
Aging is a complex biological process influenced by stochastic occurrence of molecular damage over time, but despite inherent randomness, the hallmarks of aging appear to be specific and uniform between individuals and even among species [1].
Accumulation of molecular damage?
Then the cause of molecular damage is not really important.
But the role of molecular damage distinguishes cancer and aging.
Life long accumulation of molecular damage is irrelevant to aging.
► sod-1 over-expression increases levels of cellular ROS and of molecular damage.
Despite common belief, accumulation of molecular damage does not play a key role in aging.
Definitely, developmental growth is not driven by accumulation of molecular damage, although molecular damage accumulates.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com