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The mammalian genome undergoes major reprogramming of modification patterns in germ cells and in the early embryo.
The different mechanisms result in different types of modification patterns.
The dynamics of histone modifications and the persistence of modification patterns for long periods are still largely unknown.
Moreover, comparative analysis of modification patterns across Bacteria, Archaea and Eukaryote rRNA indicates that some pseudouridylation and 2'- O-methylation modification sites may predate the diversification of the three domains of life [ 9, 10].
Another level of redundancy may exist with regard to HS epitope(s) that could originate from diverse tissues as long as these contain the appropriate combination and arrangement of modification patterns for function.
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The diversity of modification pattern in Arabidopsis H2A and the exclusive acetylation/phosphorylation preference of isoforms either on the N-terminus or on the C-terminus add additional complexity to the unique modification patterns of Arabidopsis.
We identified coexpressed NAT gene pairs that have the potential to produce NAT-siRNA as well as the coexpressed NAT gene pairs that have a strong epigenetic modification relationship (the absolute value of their PCC of modification pattern similarity is larger than 0.8).
We study how this basic biochemical characterization of covalent histone modification turnover generates the establishment, maintenance, and decay of histone modification patterns along the body of a single gene.
We also explored preservation of histone modification patterns at centromeres of human X chromosomes that had been transferred into interspecies hybrids.
However, a recently reported examination of the universalness of "histone code" reveals significant differences of histone modification patterns among species, and meanwhile, several potentially species-specific histone modifications and several novel histone modifications have been observed [12].
In this study we exploit the unique genome organization of ciliates to characterize the biological function of histone modification patterns and chromatin plasticity for the processing of specific DNA sequences during a nuclear differentiation process.
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