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In another study (Calabrese and Baldwin 2003b), we presented evidence that responses immediately below the estimated threshold (i.e., NOAEL) gave evidence of modest toxicity.
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Moreover, the modest toxicity of intronic 160R expressed at higher temperature correlated with increased DPR production, but not RNA foci.
Paclitaxel yielded overall response rates (ORR) that ranged from 16 to 27%, overall OS times of 5 11 months, and modest toxicity in several phase II trials.
This modest toxicity of Ac4GalN- n-Iso could to some extent explain why incorporation levels were lower than for the corresponding Glc and Man derivatives.
These apparently modest toxicity findings, none of which led to sustained morbidity, were matched by the patient-reported global QOL scores.
Mitoxantrone is an anthracenedione drug with mechanisms of activity similar to anthracyclines and a modest toxicity profile.
These important therapeutic results, which could at least delay the need for invasive cystectomy, were associated with very modest toxicity, underlying the importance of the experimentally derived scheme.
However, it has been reported that the administration of anti-mouse CD47 antibody to wild-type mice causes modest toxicity, principally isolated neutropenia 6.
Moreover, of the two different administration routes, the intraperitoneal injection show the modest toxicity in Bio-ZnONPs treated groups and highest toxicity in Bio-CuNPs treated groups.
There were six radiologically confirmed responses (18%) and 56% of patients demonstrated a response or stable disease, typically with only modest toxicity.
Interestingly even the dose of 60 mg m−2 used by Blackstock et al (1999) had relatively modest toxicity (only grade 3 bone marrow toxicity noted).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com