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Using the extensively validated APOE locus, we previously demonstrated that intermediate traits enhance statistical power to detect associations, even in studies of modest sample size.
The hormonal profile of BBD has generally been investigated in case control or cross-sectional studies, frequently of modest sample size, and the results are not consistent.
With regard to the quantitative study, it was a pilot, of modest sample size, and thus not powered to detect small differences in the key outcome measures.
However, multivariate genetic analyses of data from natural populations are challenging because of modest sample sizes, incomplete pedigrees, and missing data.
A number of the population clusters in the ASD study are of modest sample size (n < 100) and five population clusters could not be included because of insufficient sample numbers.
Another study, where mean DDE levels were lower (212 ng/g lipid) than in our population, reported a weak positive association between prenatal DDE concentrations and BMI in the first 3 years of life (Verhulst et al. 2009); sex differences were not reported because of modest sample size (n = 138).
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In the current study, serial assessment of a modest sample of children receiving PROMPT for idiopathic apraxia informed of a possible mechanism and neural target for therapeutic action the intervention promoted development of sensory-motor systems controlling speech production, associated with thinning and possible maturation of Wernicke's area.
Another reason could be that, in view of the modest sample sizes included, the combination of genomotyping with the subsequent statistical method is not sufficiently reproducible or robust as stochastic factors play a major role in the identification of strains used for classification.
We first analyzed another independent French group of more modest sample size (937 T2D and 1,000 NGT) (Table 2).
Because of a modest sample size used, our analysis will focus on a three-SNP analysis, although the model can deal with any number of SNPs.
The correlations that we found may be unstable because of the modest sample.
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