Flow cytometric cell cycle analyses of PaTu-8988T cells revealed only a modest influence of TTK knockdown on the relative distribution of cells across different phases of the cell cycle, thus producing no indication of induction of a cell cycle arrest following loss of TTK function.
Previous studies indicate that eIF4E mediated increased translation of select mRNAs through a 5'UTR structure[11], [43], [44].The modest influence of the 5'UTR suggests that the eIF4E sensitivity of these mRNAs may not depend solely on the efficiency of formation of the eIF4F initiation complex or on eIF4A helicase activity in particular.
The fate of such millions of DNA damaged cells is determined every hour, and even a modest influence of higher IGF-1 level on survival probability might lead to an association of circulating level with cancer risk [ 146].
The only indication that total relapses influenced any late outcome was seen in times from onset of progressive phase to DSS 6 and 8 but driven by Years 1 and 2, indicating a modest influence of these early relapses on slope of progression (Table 10).
In an attempt to break the modest influence of the CPY, the government arrested most of the party cadre, sentencing many of its members to terms far harsher than Broz's.
(4) With regard to "my out-of-school experiences," besides its modest influence on "my interest in science," it has a significant but low influence on "my future job" with an estimate on 0.143 and a t value of 2.225.
We found that both HP1α and HP1β are dispensable for DNA methylation of the ETnII/MusD family of ERVs, although HP1α has a modest influence on DNA methylation of IAP elements.
When comparing adjusted vs unadjusted ORs within studies, the former were on average 6% lower, indicating a modest influence of the individual-level confounders addressed in these studies.
There was also evidence for a modest influence of the circadian clock on resting BP, which was rhythmic in WT animals but not in Vipr2−/− mutants in constant conditions.
Concerning covariates for V1, Table 2 shows that there was only a modest influence of the body size descriptors on V1 with a trend toward an increase in V1 with LBW (P > 0.005).
