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A current episode of disorder refers to the period of maximum severity within the episode (symptom free period not greater than two months).
11 In our material, all patients were scored at the time of maximum severity during the pre-hospital phase, in line with the recommendations suggested by Alessandrini et al.
Excluding those patients with hypogammaglobulinaemia at time of first rituximab, the median time to develop hypogammaglobulinaemia was 18 months (1 65), and median time to the hypogammaglobulinaemia category of maximum severity was 35 months (1 70).
Multivariate-adjusted ORs (95% CIs) for asthma incidence, for baseline and two increasing levels of maximum severity of moisture damage (assessed by civil engineers), were 1.0, 2.8 (1.4 5.4), and 4.0 (1.6–10.2).
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ISR, injection site reactions Scores of dimensions and individual items of the questionnaire are presented according to maximum severity of pain in Figure 2 and maximum severity (size) of erythema in Figure 3, reported over an 8-day period (between D0 and D7).
The patient's own subjective view about the severity of tics and of GTS was collected by visual analogue scales (VAS): range no tic to maximum severity of tics; no GTS to maximum severity of GTS.
Subjects were counted once for maximum severity of an event, preferred term and system organ class.
BTP has historically been managed with short-acting opioids; however, these medications have a pharmacokinetic profile that does not correlate with the sudden onset and short time to maximum severity of BTP.
The WHO have described AFP as a "syndrome characterised by rapid onset of weakness of an individual's extremities, often including weakness of the muscles of respiration and swallowing, progressing to maximum severity within 1 10 days.
Severity of local and solicited adverse events was compared using cumulative logit models with main effects for dose group and CPG, with each participant scored for maximum severity events as follows: severity = 0 (no AE observed), severity = 1 (mild), severity = 2 (moderate) and severity = 3 (severe).
The distribution of overall maximum severity per volunteer of local and systemic reactogenicity events was used to assess the differences between dosage groups.
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