After submitting the list of identifiers, the application maps them onto an interaction network (Section 4), and computes topological properties for the entire network, the uploaded gene/protein set and random sets of matched sizes.
For each of the six sizes of regions, comparisons were made between the three types of "defined" regions (cis-eQTL clusters, control clusters, and regions centered on single cis-eQTLs) and the fourth type of region, consisting of random regions of matching size.
A cross-validation test confirmed that the held-out SGLs received significantly higher SE scores than the held-out DGLs (t = 8.777; p-value = 6.204e-16; Welch two-sample t-test; Figure 6A) and each was higher than random control modules of matching sizes (t = 4.802; paired7e-06; paired Student t-test; Figure S2c d).
Beginning from starting position, different defined window sizes lead to several sequence cutouts of matching sizes.
Representative examples that compare two cis-eQTL clusters and control clusters of matching sizes are shown in Figure 3. Altogether, polymorphic SINEs appeared to be a signature characteristic of cis-eQTL regions.
Thus, perhaps what matters is not the absolute area size, but the matched size of the connected regions.
a: weighted according to the matched sizes of cases.
The same number of plots, in matching sizes, was established in nearby continuous forest (referred to as intact forest plots).
Briefly, we designed test primer pairs of matched product size amplifying DEFB103 (5′-TATTATTGCAGAGTCAGAGGTGGCCG-3′ and 5′-GTGTCGAGCACTTGCCAATCTGTT-3′) and DEFB2L (5′-TACTGCTGCAGACACTCTGCCC-3′ and 5′-TGAACCTGCGGTGGCCTCGT-3′).
The results of matched sample-size groups were similar to those of the complete groups, and were reported in detail.
> -wrap-foot>> -wrap-fooTheThe numbers of matched polyps (all sizes) are indicated per reader.
